Rare Thyroid Disorders:
Sequoia Medical 360

Expert Care for Complex and Rare Thyroid Conditions in Bronxville & Westchester, NY

While hypothyroidism, hyperthyroidism, and thyroid nodules are the most common thyroid problems, many patients develop less common but equally significant disorders that require nuanced evaluation. These conditions often go undiagnosed or mismanaged in general practice, leading to prolonged symptoms, unnecessary medications, or overlooked risks.
At Sequoia Medical 360, Dr. Tony Mathews’ advanced training in Endocrinology and Preventive Cardiology equips him to identify and manage even the rarest thyroid disorders. With a concierge model offering extended visits, expedited diagnostics, and direct access to your physician, you receive the level of precision and oversight these conditions demand.

Inflammatory & Transient Thyroid Disorders

Subacute Thyroiditis

Often following a viral illness, this condition causes painful thyroid inflammation. Patients may experience neck tenderness, fever, fatigue, and an initial phase of hyperthyroidism followed by hypothyroidism as the gland heals.

Diagnosis: Elevated inflammatory markers, abnormal thyroid function tests, and ultrasound findings.
Treatment: Anti-inflammatories, beta-blockers during the hyperthyroid phase, and short-term thyroid hormone replacement if hypothyroidism develops.

Postpartum Thyroiditis

Occurs within a year of childbirth due to autoimmune thyroid inflammation triggered by immune system shifts.

Symptoms: Temporary hyperthyroid phase (palpitations, anxiety, weight loss), often followed by hypothyroidism (fatigue, weight gain, depression).
Management: Close monitoring, symptom control, and thyroid replacement if hypothyroidism becomes persistent. Many women recover fully, but recurrence in future pregnancies is common.

Severe or Life-Threatening Thyroid Emergencies

Myxedema Coma

A rare, extreme form of untreated hypothyroidism leading to confusion, hypothermia, slowed heart rate, and potentially coma.

Triggers: Severe infection, surgery, or long-undiagnosed hypothyroidism.
Management: Immediate ICU-level care with IV thyroid hormone and supportive therapy. At Sequoia, our proactive monitoring aims to prevent hypothyroidism from ever progressing this far.

Thyroid Storm

The hyperthyroid counterpart to myxedema coma, thyroid storm is a crisis of dangerously elevated thyroid hormone levels.

Symptoms: High fever, severe tachycardia, delirium, and multi-organ strain.
Management: Emergency hospitalization with high-dose antithyroid drugs, beta-blockers, corticosteroids, and supportive measures.Early recognition and treatment of hyperthyroidism greatly reduces this risk.

Central & Genetic Thyroid Disorders

Central Hypothyroidism

Unlike primary hypothyroidism, where the thyroid itself is underactive, central hypothyroidism originates from the pituitary or hypothalamus failing to signal the thyroid appropriately.

Symptoms: Fatigue, weight gain, constipation, and cold intolerance, similar to primary hypothyroidism.
Diagnosis: Low thyroid hormones with inappropriately low or normal TSH.
Management: Tailored thyroid hormone replacement with close monitoring, often in conjunction with evaluation of other pituitary hormones.

Thyroid Hormone Resistance

A rare genetic condition where the body produces normal or high thyroid hormone, but tissues fail to respond.

Symptoms: Mixed picture — some signs of hyperthyroidism (rapid heart rate, anxiety), alongside features of hypothyroidism (fatigue, weight gain).
Diagnosis: High T4/T3 with non-suppressed TSH; often confirmed with genetic testing.
Management: Highly individualized; sometimes requires selective T3 therapy or symptom-based treatment.

Other Autoimmune or Structural Thyroid Conditions

Thyroid Eye Disease (Graves’ Ophthalmopathy)

Although most often linked with Graves’ disease, thyroid eye disease can sometimes occur independently.

Symptoms: Bulging eyes, dryness, double vision, and in severe cases, vision-threatening compression of the optic nerve.
Management: Collaborative care with ophthalmology, addressing both thyroid hormone balance and eye-specific therapies (steroids, biologics, surgery)

Toxic Adenoma / Multinodular Goiter

Autonomously functioning thyroid nodules can cause persistent hyperthyroidism without the diffuse stimulation seen in Graves’ disease.

Diagnosis: Radioactive iodine uptake scans showing focal or patchy activity.
Treatment: Medications, radioiodine therapy, or surgery depending on severity and patient preference.

Euthyroid Sick Syndrome (Non-Thyroidal Illness Syndrome)

Seen in critically ill patients, thyroid hormone levels may appear abnormal without intrinsic thyroid disease.

Management: Focuses on treating the underlying illness rather than unnecessary thyroid medication

Our Diagnostic & Treatment Approach

At Sequoia Medical 360, rare thyroid conditions are evaluated with the same rigor as more common disorders. Our comprehensive work-up may include:

Full thyroid panels (TSH, free T3, free T4) and advanced antibody testing.
High-resolution ultrasound to assess gland structure and vascularity.
Pituitary hormone testing when central dysfunction is suspected.
Inflammatory and metabolic markers to detect systemic drivers.
Body composition analysis (InBody 770) to monitor muscle, fat, and metabolic changes.

Treatment is always personalized, balancing thyroid optimization with your overall cardiovascular, bone, and metabolic health.

The Sequoia Medical 360 Advantage

Expertise in complex endocrinology: Rare conditions require nuanced interpretation — our training ensures no subtlety is missed.
Direct Physician Counsel: Ample, scheduled exam time and streamlined communication to review results with the depth your physiology requires.
Integrated care model: We connect thyroid management with cardiovascular prevention, bone health, and longevity medicine.
Telehealth across New York State: Expertise available wherever you are.

Restore Balance, Even in Complex Thyroid Disorders

When symptoms don’t fit the usual patterns, Sequoia Medical 360 provides the clarity you need. From postpartum thyroiditis to thyroid hormone resistance, our comprehensive evaluations and personalized care plans ensure no condition is overlooked.

Meet Dr. Mathews
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SQMed360.com
Located in Bronxville, serving Westchester & all of New York State.
(914) 292-0300
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